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Medication makes the doctor's job a bit easier, not to mention easing the discomfort of the patient. In ancient Rome, for prescription they used a variety of substances for cures and as anesthetic for surgery.

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Although Hippocrates of Cos (c.460-380 BCE) is considered to be the "Father of Medicine" little is known about him. It is generally accepted that he was roughly a contemporary of Socrates and was a practicing physician. It also seems likely that Hippocrates would have been an Asclepiad. The Asclepiads were members of a guild of physicians which traced its origins to Asclepius, the god of healing by ancient Greeks. Tradition also tells us that Hippocrates was the most famous physician and teacher of medicine of his time. Over 60 medical treatises that have traditionally been attributed to him. These treatises are collectively referred to as the Hippocratic Corpus. Most of these treatises, however, were not written by Hippocrates himself. In fact, several of the existent treatises were written well after the life of Hippocrates. The treatises themselves were written over about a two hundred year period and range in date from c.510-c.300 BCE, so clearly one man could not have authored all of them. Although It is likely that Hippocrates did compose some of the treatises, none of the 60 treatises can positively be attributed to Hippocrates. Therefore at times they contain conflicting materials and different ideas. In the main, however, they are similar in looking for natural explanations and treatments of illness and rejecting sorcery and magic.

Medicine was a jumble of efforts, trials and errors. It was not anything like the systematic science it is today. Its effects were not always reliable, and during the Republic especially the medical profession was a target for mistrust and ridicule. The physician had a very low social status.

The quackery and the honest efforts both made use of some treatments that would be considered strange or even ridiculous today. As a cure for fractured ribs Pliny the Elder (not a physician but a writer on natural science) favored a mixture of wine and goat's manure.

In addition, the nature of the society encouraged a fear of poisoning, and this fear opened the door for doctors to promote antidotes. Roman medicine was thoroughly mixed with religious and supernatural elements. For example, the cult of Asklepios (Latin: Aesculapius), patron god of healing, thrived from around 500 B.C. until 500 A.D. With its sanctuary at Epidauros, in Greece, the cult served as a center of healing for the entire Roman province of Asia. Sick or injured persons from anywhere in the Empire would make the journey to Epidauros, hoping to be healed. Typically they would sleep in a special room called the Abaton. Dreams sent from Aesculapius would come to them and heal their ailments. With inscriptions, attendants at the shrine would record the dreams and their miraculous results, so that today we have evidence of what went on at Epidauros.